This one came from one of my colleagues. If you are having trouble implementing asp.net Ajax using the asp:ScriptManager in a Sitecore website, you should check for the following:
- Add the /scriptresource.axd to the IgnoreUrlPrefixes setting in your web.config.
(one of the symptoms that the settings is required is that you get a “Sys is undefined” script error) - Add the path to your webservice to the IgnoreUrlPrefixes setting in your web.config
If the path to the web service is /components/MyComponent/MyService.asmx, you should add this path as well.